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    Nature Reviews Cancer - Wikipedia ; Nature Reviews Cancer is a monthly review journal covering the field of oncology . show. v · t · e · Holtzbrinck Publishing Group. Holtzbrinck. DIE ZEIT ... PTEN, Stem Cells, and Cancer Stem Cells - The Journal of ... ; 1 May 2009 ... In this review, we will focus on the role of PTEN and its controlled ..... The Cancer Genome Atlas Research Network (2008) Nature 455, 1061– ... Allelic imbalance and mutations of the PTEN gene in ovarian ... ; 15 Jan 2000 ... The PTEN/MMAC1/TEP1 tumor‐suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of ...PTEN loss in biopsy tissue predicts poor clinical outcomes ... ; PTEN loss at the time of biopsy seems to predict time to development of metastasis, prostate cancer‐specific mortality and, for the first time, castration‐resistant prostate cancer and response to androgen deprivation therapy after radical prostatectomy. Promoter methylation of the PTEN gene is a common ... ; About 25–50% of women with Cowden disease, a syndrome associated with germ‐line mutations of the PTEN gene (at 10q23), develop breast cancer (BC), but PTEN mutations have been found in only 5% of sporadic BCs. However, 29–48% of BCs display loss of heterozygosity in 10q23, and about 40% of BCs show a decrease or absence of PTEN protein levels at the time of diagnosis. Nature Reviews - The tumour suppressor PTEN regulates ... ; The tumour suppressor PTEN regulates various cellular processes, including maintenance of genomic stability, cell survival, migration, proliferation and... PTEN gene interactions and correlations with ... ; These are the sources and citations used to research PTEN gene interactions and correlations with tumourigenesis. This bibliography was generated on Cite This For Me on Wednesday, September 9, 2015 MGMT and PTEN as potential prognostic markers in breast ... ; MGMT and PTEN as potential prognostic markers in breast cancer. ... Approximately 50% of patients with breast cancer harbor a mutation in PTEN or have lost at least 1 copy of PTEN. ... Nature Reviews. Cancer, 8 (2008), pp. 193-204. Google Scholar. Jacinto and Esteller, 2007. PTEN function, the long and the short of it - Europe PMC ... ; The importance of PTEN in tumor suppression is confirmed by the existence of germline mutations of PTEN in the PTEN Hereditary Tumor Syndromes (PHTS) including Cowden disease, Bannayan-Riley-Ruvalcaba Syndrome, Proteus syndrome, and Proteus like syndrome [18–20].Patients with PHTS develop benign hamartomas in a variety of organs, and are more likely to develop thyroid or breast cancer []. PTEN Mutations as a Cause of Constitutive Insulin ... ; Original Article from The New England Journal of Medicine — PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity ... Germline PTEN mutations cause a cancer ... To describe ... The functions and regulation of the PTEN tumour suppressor ... ; The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular ... Expert Reviews in Molecular Medicine - cambridge.org ; Nature Reviews. Cancer 4, 579-591. 150 ... (2009) Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. Journal of Clinical Oncology 27, 3297-3302. ... 159 He, L. et al. (2010) The critical role of AKT2 in hepatic steatosis induced by PTEN loss. American Journal of Pathology 176, 2302 ... Preclinical Remodeling of Human Prostate Cancer through ... ; Knowledge gained from the identification of genetic and epigenetic alterations that contribute to the progression of prostate cancer in humans is now being implemented in the development of functionally relevant translational models. GEM (genetically modified mouse) models are being developed to incorporate the same molecular defects associated with human prostate cancer.PTEN gains new powers | Nature Reviews Cancer ; 24 Sep 2015 ... Caserta et al. investigated the effects of a cancer-associated mutation in PTEN ( PTENFV). They generated PtenFV knock-in mice: the ... Tumours and tremors: how PTEN regulation underlies both - Nature ; 21 Feb 2006 ... Mini Review. ... work examining PTEN regulation and its implications for the development of both cancer and neurodegenerative disease. Molecular Pathways: Intercellular PTEN and the Potential of PTEN ... ; Clinical cancer research : an official journal of the American Association for Cancer ... Here we review PTEN's role as a multifaceted tumor suppressor and reflect .... specific detriments caused by PTEN deficiency, the multifaceted nature of the ... The functions and regulation of the PTEN tumour suppressor: new ... ; Abstract: PTEN is a potent tumour suppressor, and its loss of function is ... Nature Reviews. ... Type: Review, Research Support, U.S. Gov't, Non-P.H.S., Journal Article, ... Even a subtle decrease in PTEN levels and activity results in cancer ... PTEN: Multiple Functions in Human Malignant Tumors - NCBI ; 16 Feb 2015 ... Tumor-associated mutations may occur in all PTEN domains, thus implying that ... In this review, we will discuss the cellular functions controlled by PTEN, the ..... and Cellular Oncology, a section of the journal Frontiers in Oncology. ..... Nature ( 2013) 499(7456):43–9.10.1038/nature12222 [PMC free article] ... PTEN | Annual Review of Biochemistry - Annual Reviews ; The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which op... ... JOURNALS A-Z · Analytical Chemistry ... Regulation of PTEN expression by noncoding RNAs | Journal of ... ; 10 Sep 2018 ... Review; Open Access; Published: 10 September 2018 ... PTEN expression alteration is crucial to the pathogenesis of cancer and other diseases. ...... HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. Natural compound found in broccoli reawakens the function of ... ; 16 May 2019 ... Long associated with decreased risk of cancer, broccoli and other cruciferous vegetables ... A well-known and potent tumor suppressive gene, PTEN is one of the most frequently ... Journal Reference: .... About This Site | Staff | Reviews | Contribute | Advertise | Privacy Policy | Editorial Policy | Terms of Use. De Novo PTEN Mutation in a Young Boy with Cutaneous Vasculitis ; 4 Apr 2017 ... PTEN acts as a tumor suppressor gene by negatively regulating PI3K-Akt and .... 3-kinase pathway in cancer,” Nature Reviews Drug Discovery, vol. 8, no. ... with PTEN mutations,” American Journal of Medical Genetics, vol.PTEN Gene and Integrin Signaling in Cancer | JNCI: Journal ... ; JNCI: Journal of the National Cancer Institute, Volume 91, Issue 21, 3 November 1999, .... [For a recent review on the genetics of PTEN, see Ali et al. ...... protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature. Breast tissue tumor suppressor PTEN: A potential Achilles ... ; 1 Aug 2018 ... In an article published July 17, 2018 by Nature Communications, a highly collaborative ... In human breast cancer, expression of the tumor suppressor PTEN and the cell growth ... Journal Reference: .... About This Site | Staff | Reviews | Contribute | Advertise | Privacy Policy | Editorial Policy | Terms of Use. Chromatin remodeling ATPase BRG1 and PTEN are ... - JCI ; 29 Nov 2018 ... Research ArticleCell biologyOncology Free access | 10.1172/JCI123557. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer ...... The use of pathological specimens and the review of all pertinent ... senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005 ... With Regard to PTEN Promoter Testing for Hereditary Cancer ... ; 23 Feb 2018 ... To review briefly, Black et al assessed cancer risks in individuals who ... The initial published reports that explored PTEN promoter variants ... Nature 536:285- 291, 2016 Crossref, Google Scholar ... Subscribe to this Journal ... Beyond PTEN mutations: the PI3K pathway as an integrator of ... ; DJ1 is a novel regulator of the PI3K–PTEN pathway and is associated with breast ... Tak W Mak; Published in Nature Reviews Cancer 2006; DOI:10.1038/nrc1819 ... Clinical cancer research : an official journal of the American Association for ... PTEN Physically Interacts with and Regulates E2F1-mediated ... ; 31 May 2018 ... This Journal. Advanced search. Publication Cover. Journal ... PTEN-4A physically interacted with the transcription factor E2F1 and ... Consistent with these findings, we observed increased PTEN phosphorylation and reduced nuclear PTEN levels in lung cancer ...... Nature Reviews Molecular Cell Biol. 2012 ... Selective eradication of cancer displaying hyperactive Akt by ... ; 24 Apr 2018 ... As PTEN is lost in approximately 40% of prostate cancers (Pourmand ...... Nature Reviews Cancer 16:635–649. .... Urology Journal 4:95–100. Prostate-specific deletion of the murine Pten tumor suppressor ... ; Journal home page for Cancer Cell ... The murine Pten prostate cancer model described in this study recapitulates the disease ..... for chromogranin A and synaptophysin (SNP) (for review, see Sciarra et al., 2003). ..... Nature, 406 (2000), pp. Tumor Suppressor PTEN in Breast Cancer: Heterozygosity ... ; Our data suggest an association between breast cancer and PTEN mutations ... Mutations in both alleles of the PTEN gene arise during cancer progression in various ..... Nature 441: 424-430, 2006. ... Nat Rev Drug Discov 4: 988-1004, 2005. ...... article is cited · Alert me if a correction is posted · Similar articles in this journal. 地獄の火 テキスト
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  • #5
    Thanks.

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  • #6
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  • #7
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    Topic is closed

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